Mortality and Cardiovascular Disease Among Older Live Kidney Donors

Over the past two decades, live kidney donation by older individuals (≥55 years) has become more common. Given the strong associations of older age with cardiovascular disease (CVD), nephrectomy could make older donors vulnerable to death and cardiovascular events. We performed a cohort study among...

Full description

Saved in:
Bibliographic Details
Published in:American journal of transplantation 2014-08, Vol.14 (8), p.1853-1861
Main Authors: Reese, P. P., Bloom, R. D., Feldman, H. I., Rosenbaum, P., Wang, W., Saynisch, P., Tarsi, N. M., Mukherjee, N., Garg, A. X., Mussell, A., Shults, J., Even‐Shoshan, O., Townsend, R. R., Silber, J. H.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biological and medical sciences
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Epidemiology
Ethics and public policy
Female
Follow-Up Studies
General aspects
Health risk assessment
health services and outcomes research
Humans
Kidney Transplantation
kidney transplantation/nephrology
kidney transplantation: living donor
Living Donors
Longitudinal Studies
Male
Medical sciences
Medicare
Middle Aged
Mortality
Nephrectomy
organ procurement
Public health. Hygiene
Public health. Hygiene-occupational medicine
Quality of Life
Renal Insufficiency - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Time Factors
Treatment Outcome
United States
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the past two decades, live kidney donation by older individuals (≥55 years) has become more common. Given the strong associations of older age with cardiovascular disease (CVD), nephrectomy could make older donors vulnerable to death and cardiovascular events. We performed a cohort study among older live kidney donors who were matched to healthy older individuals in the Health and Retirement Study. The primary outcome was mortality ascertained through national death registries. Secondary outcomes ascertained among pairs with Medicare coverage included death or CVD ascertained through Medicare claims data. During the period from 1996 to 2006, there were 5717 older donors in the United States. We matched 3368 donors 1:1 to older healthy nondonors. Among donors and matched pairs, the mean age was 59 years; 41% were male and 7% were black race. In median follow‐up of 7.8 years, mortality was not different between donors and matched pairs (p = 0.21). Among donors with Medicare, the combined outcome of death/CVD (p = 0.70) was also not different between donors and nondonors. In summary, carefully selected older kidney donors do not face a higher risk of death or CVD. These findings should be provided to older individuals considering live kidney donation. In this matched cohort study, 3,368 older (≥55 years) live kidney donors in the United States have no difference in mortality, cardiovascular disease, or diabetes rates compared to healthy older nondonors.
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12822