Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves

Magnetic particles are versatile imaging agents that have found wide spread applicability in diagnostic, therapeutic, and rheology applications. In this study, we demonstrate that mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue v...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical optics express 2014-07, Vol.5 (7), p.2349-2361
Main Authors: Ahmad, Adeel, Kim, Jongsik, Sobh, Nahil A, Shemonski, Nathan D, Boppart, Stephen A
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Magnetic particles are versatile imaging agents that have found wide spread applicability in diagnostic, therapeutic, and rheology applications. In this study, we demonstrate that mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue viscoelastic properties using magnetomotive optical coherence elastography. We show these capabilities in tissue mimicking elastic and viscoelastic phantoms and in biological tissues by measuring the shear wave speed under magnetomotive excitation. Furthermore, we demonstrate the extraction of the complex shear modulus by measuring the shear wave speed at different frequencies and fitting to a Kelvin-Voigt model.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.5.002349