Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis

Systemic inflammation is a well-known risk factor for diseases such as atherosclerosis and is augmented by the presence of obesity. In addition, it has been shown that inflammation may be negatively influenced by certain macronutrients, specifically the omega-3 and omega-6 fatty acids. The primary a...

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Bibliographic Details
Published in:International Journal of Obesity 2012-06, Vol.36 (6), p.797-804
Main Authors: STEFFEN, B. T, STEFFEN, L. M, TRACY, R, SISCOVICK, D, HANSON, N. Q, NETTLETON, J, TSAI, M. Y
Format: Article
Language:English
Subjects:
Adults
Aged
Aged, 80 and over
Analysis
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Atherosclerosis - ethnology
Atherosclerosis - physiopathology
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Blood diseases
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cardiovascular disease
Cohort Studies
Complications and side effects
Cytokines
Diagnosis
Diet (effects)
Diet (weight control)
Disease Progression
E-Selectin - blood
Endothelium, Vascular - metabolism
Epidemiology
Fatty acids
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-6 - blood
Female
General aspects
Humans
Inflammation
Inflammation - blood
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Linear Models
Linoleic Acid - blood
Lipids
Male
Medical sciences
Medicine
Metabolic diseases
Middle Aged
Obesity
Obesity - blood
Obesity - ethnology
Obesity - physiopathology
Pathology
Physiological aspects
Plasma
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk factors
Tumor necrosis factor-TNF
Unsaturated fatty acids
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Summary:Systemic inflammation is a well-known risk factor for diseases such as atherosclerosis and is augmented by the presence of obesity. In addition, it has been shown that inflammation may be negatively influenced by certain macronutrients, specifically the omega-3 and omega-6 fatty acids. The primary aim of this study is to determine whether obesity modifies the association between plasma phospholipid polyunsaturated fatty acids (PUFAs) and markers of inflammation and endothelial activation in Multi-Ethnic Study of Atherosclerosis (MESA) participants. A sample of 2848 adults (25% African American, Chinese, Hispanic, and White) randomly selected from the MESA cohort. Relative plasma PUFA concentrations were determined using gas chromatography-flame ionization detection. Levels of three inflammatory markers (high-sensitivity C-reactive protein, interleukin (IL)-6 and tumor necrosis factor-receptor 1) and two endothelial activation markers (soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin) were determined with enzyme immunoassays. Linear regression analysis was used to evaluate the relationship between these markers and plasma PUFAs. Obesity modified the associations of linoleic acid (P(int)=0.01), dihomo-γ-linolenic (P(int)=0.07) and eicosapentaenoic acid (EPA) (P(int)=0.04) with sICAM-1 concentrations; in addition, obesity modified the association of IL-6 with dihomo-γ-linolenic (P(int)=0.01). In obese individuals, sICAM-1 was inversely related to EPA levels (P=0.02), but directly related to linoleic acid levels (P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2011.157