Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophil...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2012-09, Vol.130 (3), p.607-612.e9
Main Authors: Valent, Peter, MD, Klion, Amy D., MD, Horny, Hans-Peter, MD, Roufosse, Florence, MD, PhD, Gotlib, Jason, MD, Weller, Peter F., MD, Hellmann, Andrzej, MD, Metzgeroth, Georgia, MD, Leiferman, Kristin M., MD, Arock, Michel, PharmD, PhD, Butterfield, Joseph H., MD, Sperr, Wolfgang R., MD, Sotlar, Karl, MD, Vandenberghe, Peter, MD, PhD, Haferlach, Torsten, MD, Simon, Hans-Uwe, MD, PhD, Reiter, Andreas, MD, Gleich, Gerald J., MD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Biological and medical sciences
Chromosomes
Classification
Clinical trials
Conferences
criteria
Cytokines
Defects
Disease
Eosinophilia
Eosinophilia - classification
Eosinophilia - diagnosis
eosinophilic leukemia
Eosinophils - physiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Hematologic and hematopoietic diseases
Humans
hypereosinophilia of undetermined significance
Hypereosinophilic syndrome
Hypereosinophilic Syndrome - classification
Hypersensitivity
Immunology
Immunopathology
Leukemia
Leukocytes (eosinophilic)
Life Sciences
Lymphatic system
Medical sciences
Other diseases. Hematologic involvement in other diseases
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Stem cells
Terminology as Topic
Thrombosis
Tumors
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Description
Summary:Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2012.02.019