Significance of serum IgA in patients with acute hepatitis E virus infection

AIM： To study the significance of serum anti-hepatitis E virus （HEV） IgA in patients with hepatitis E. METHODS： A new method was established to assay anti-HEY IgA, which could be detected in the middle phase of the infection. We compared anti-HEV IgA assay with anti-HEV IgM and anti-HEV IgG assay in...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-06, Vol.12 (24), p.3919-3923
Main Authors: Tian, De-Ying, Chen, Yan, Xia, Ning-Shao
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis Antibodies - blood
Hepatitis E - blood
Hepatitis E - diagnosis
Hepatitis E - immunology
Hepatitis E virus - genetics
Hepatitis E virus - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin A - immunology
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Male
Middle Aged
Rapid Communication
RNA, Viral - analysis
戊型病毒肝炎
病毒感染
血清IgA
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Summary:AIM： To study the significance of serum anti-hepatitis E virus （HEV） IgA in patients with hepatitis E. METHODS： A new method was established to assay anti-HEY IgA, which could be detected in the middle phase of the infection. We compared anti-HEV IgA assay with anti-HEV IgM and anti-HEV IgG assay in sera from 60 patients with positive HEV-RNA. RESULTS： The 60 patients with positive HEV-RNA had both anti-HEV IgA and anti-HEV IgM and 410 patients with negative HEV-RNA were used as control. Periodic serum samples obtained from 60 patients with hepatitis E were tested for HEV RNA, anti-HEV IgM, anti-HEV IgA and anti-HEV IgG. Their HEV-RNA was detectable in the serum until 20 ±11 d. We used anti-HEV IgM and anti-HEV IgA assay to detect HEV infection and positive results were found in 90 ± 15 d and 120 ±23 d respectively, the positive rate of anti-HEV IgA was higher than that of anti-HEV IgM and HEV-RNA （P 〈0.05）. CONCLUSION： The duration of anti-HEV IgA in serum is longer than that of anti-HEV IgM, and anti-HEV IgA assay is a good method to detect HEV infection.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i24.3919