Neuropeptide Y in the rostral ventromedial medulla reverses inflammatory and nerve injury hyperalgesia in rats via non-selective excitation of local neurons

Highlights • NPY in the RVM reverses mechanical hyperalgesia from nerve injury and inflammation. • In naïve animals, NPY in the RVM produces mild thermal hypoalgesia. • NPY increases firing of both pain-inhibiting and pain-facilitating RVM neurons. • Pain relief from NPY in the RVM is best explained...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2014-06, Vol.271, p.149-159
Main Authors: Cleary, D.R, Roeder, Z, Elkhatib, R, Heinricher, M.M
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Analgesics - pharmacology
Animals
Biological and medical sciences
descending pain modulation
Dose-Response Relationship, Drug
Freund's Adjuvant
Fundamental and applied biological sciences. Psychology
Hot Temperature
Hyperalgesia - drug therapy
Hyperalgesia - physiopathology
Inflammation - physiopathology
Male
Medical sciences
Medulla Oblongata - drug effects
Medulla Oblongata - physiopathology
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neural Inhibition - drug effects
Neural Inhibition - physiology
Neurology
Neurons - drug effects
Neurons - physiology
Neuropeptide Y - pharmacology
nociception
Nociceptive Pain - drug therapy
Nociceptive Pain - physiopathology
NPY
OFF-cells
ON-cells
Pain Threshold - drug effects
raphe magnus
Rats, Sprague-Dawley
Receptors, Neuropeptide Y - metabolism
Serotonergic Neurons - drug effects
Serotonergic Neurons - physiology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Spinal Nerves - injuries
Touch
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • NPY in the RVM reverses mechanical hyperalgesia from nerve injury and inflammation. • In naïve animals, NPY in the RVM produces mild thermal hypoalgesia. • NPY increases firing of both pain-inhibiting and pain-facilitating RVM neurons. • Pain relief from NPY in the RVM is best explained by increased OFF-cell activity.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.04.035