Hepatic adenomatosis associated with hormone replacement therapy and hemosiderosis： A case report

We have reported a case of hepatic adenomatosis associated with hormone replacement therapy （estrogen and progesterone） and hemosiderosis caused by excessive blood transfusion for the treatment of chronic myeloid leukemia. A 34-year-old woman was found to have several hepatic tumors on a routine med...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-01, Vol.12 (4), p.652-655
Main Authors: Hagiwara, Satoshi, Takagi, Hitoshi, Kanda, Daisuke, Sohara, Naondo, Kakizaki, Satoru, Katakai, Kenji, Yoshinaga, Teruo, Higuchi, Tsugio, Nomoto, Kenichi, Kuwano, Hiroyuki, Mori, Masatomo
Format: Article
Language:English
Subjects:
Adenoma - etiology
Adenoma - pathology
Adult
Case Report
Diagnosis, Differential
Estrogen Replacement Therapy - adverse effects
Female
Hemosiderosis - complications
Hemosiderosis - etiology
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Transfusion Reaction
Whole-Body Irradiation - adverse effects
含铁血黄素沉着症
激素治疗
肝肿瘤
雌激素
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Summary:We have reported a case of hepatic adenomatosis associated with hormone replacement therapy （estrogen and progesterone） and hemosiderosis caused by excessive blood transfusion for the treatment of chronic myeloid leukemia. A 34-year-old woman was found to have several hepatic tumors on a routine medical examination. The general condition was good. Laboratory studies showed iron overload. Abdominal computed tomography and selective hepatic angiography showed several hypervascular tumors in the right lobe of the liver （up to 20 mm in diameter）. Since hepatocellular carcinoma could not be ruled out, subsegmental hepatectomy was performed. Histopathological examination of the surgical specimen showed hepatic adenomatosis with hemosiderosis. Both hormone replacement therapy and iron overload could be the cause of hepatic adenomatosis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i4.652