Leptin levels in the differential diagnosis between benign and malignant ascites

AIM： To evaluate the role of leptin levels in the differentia diagnosis of ascites. METHODS： Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites （35 with malignancies, 30 cirrhosis and 12 tuberculosis）. Control serum samples were obtained from 20 healthy subjects....

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-01, Vol.13 (3), p.398-402
Main Authors: Buyukberber, Mehmet, Koruk, Mehmet, Savas, M-Cemil, Gulsen, Murat-T, Pehlivan, Yavuz, Deveci, Rukiye, Sevinc, Alper, Gergerlioglu, Serdar
Format: Article
Language:English
Subjects:
Adult
Aged
Ascites - diagnosis
Ascites - metabolism
Clinical Research
Diagnosis, Differential
Female
Humans
Leptin - blood
Leptin - metabolism
Male
Middle Aged
Prospective Studies
Tumor Necrosis Factor-alpha - metabolism
结核病
诊断方法
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Summary:AIM： To evaluate the role of leptin levels in the differentia diagnosis of ascites. METHODS： Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites （35 with malignancies, 30 cirrhosis and 12 tuberculosis）. Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by EUSA. Body mass index （BMI） and percentage of body fat （BFM） by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS： In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION： In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v13.i3.398