Congestive heart failure: a case of protein misfolding

This article describes an interesting case of a patient presenting with congestive heart failure found to have restrictive cardiomyopathy with initial laboratory evaluation showing hypogammaglobuminemia without a monoclonal band on serum and urine electrophoresis. This case highlights the clinically...

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Bibliographic Details
Published in:Hawai'i journal of medicine & public health 2014-06, Vol.73 (6), p.172-174
Main Authors: Ha, Chung-Eun, Bhagavan, Nadhipuram V, Loscalzo, Miki, Chan, Stephen K, Nguyen, Huy V, Rios, Carlos N, Honda, Stacey A A
Format: Article
Language:English
Subjects:
Aged
Amyloidosis - diagnosis
Amyloidosis - etiology
Heart Failure - diagnosis
Heart Failure - etiology
Humans
Male
Multiple Myeloma
Proteostasis Deficiencies - complications
Proteostasis Deficiencies - diagnosis
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Summary:This article describes an interesting case of a patient presenting with congestive heart failure found to have restrictive cardiomyopathy with initial laboratory evaluation showing hypogammaglobuminemia without a monoclonal band on serum and urine electrophoresis. This case highlights the clinically significant cardiac manifestation caused by protein misfolding, a defect in protein homeostasis. In addition, the utility of a relatively newer laboratory test, serum free light chains as well as the importance of clinical and pathophysiologic correlation is also discussed. We present a relatively uncommon cause of heart disease, cardiac amyloidosis in a patient with a systemic plasma cell dyscrasia, and multiple myeloma.
ISSN:2165-8218
2165-8242