Bronchoalveolar Lavage Fluid and Serum Canine Surfactant Protein A Concentrations in Dogs with Chronic Cough by Bronchial and Interstitial Lung Diseases

We measured bronchoalveolar lavage fluid (BALF) and serum canine surfactant protein (cSP)-A concentrations in dogs with chronic cough. There were no significant differences between bronchial and interstitial lung diseases in BALF cSP-A concentrations. However, serum cSP-A concentrations in dogs with...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2014, Vol.76(4), pp.593-596
Main Authors: YAMAYA, Yoshiki, SUZUKI, Kazuyuki, WATARI, Toshihiro, ASANO, Ryuji
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Biomarkers - metabolism
Bronchial Diseases - blood
Bronchial Diseases - complications
Bronchial Diseases - metabolism
Bronchial Diseases - veterinary
Bronchoalveolar Lavage Fluid - chemistry
canine
chronic cough
Clinical Pathology
Cough - etiology
Cough - veterinary
Dog Diseases - blood
Dog Diseases - metabolism
Dogs
Enzyme-Linked Immunosorbent Assay - veterinary
Lung Diseases, Interstitial - blood
Lung Diseases, Interstitial - complications
Lung Diseases, Interstitial - metabolism
Lung Diseases, Interstitial - veterinary
Pulmonary Surfactant-Associated Protein A - blood
Pulmonary Surfactant-Associated Protein A - metabolism
SP-A
Statistics, Nonparametric
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Summary:We measured bronchoalveolar lavage fluid (BALF) and serum canine surfactant protein (cSP)-A concentrations in dogs with chronic cough. There were no significant differences between bronchial and interstitial lung diseases in BALF cSP-A concentrations. However, serum cSP-A concentrations in dogs with the interstitial lung disease as diffuse panbronchiolitis and idiopathic pulmonary fibrosis were significantly higher than those in dogs with the bronchial disease as chronic bronchitis. These results suggest that serum cSP-A concentrations may be a useful and noninvasive biomarker to understand the existence of interstitial lung damage in dogs with chronic cough.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.13-0428