Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat

Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2014, Vol.76(4), pp.553-557
Main Authors: WATANABE, Shinya, ITO, Jumpei, BABA, Takuya, HIRATSUKA, Takahiro, KUSE, Kyohei, OCHI, Haruyo, ANAI, Yukari, HISASUE, Masaharu, TSUJIMOTO, Hajime, NISHIGAKI, Kazuo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Cat Diseases - genetics
Cat Diseases - virology
Cats
Cloning, Molecular
DNA Primers - genetics
feline leukemia virus
Female
Gene Components
Genes, env - genetics
HEK293 Cells
Humans
hypercalcemia
Leukemia Virus, Feline - genetics
Leukemia Virus, Feline - physiology
Leukemia, Feline - genetics
Leukemia, Feline - virology
Luciferases
lymphoma
Molecular Sequence Data
Notch2
Polymerase Chain Reaction - veterinary
Receptor, Notch2 - genetics
Receptor, Notch2 - metabolism
Sequence Alignment
Sequence Analysis, DNA - veterinary
transduction
Transduction, Genetic - veterinary
Virology
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Summary:Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.13-0344