Production and pathogenicity of hepatitis C virus core gene products

Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes mellitus.HCV,belonging to the Flaviviridae family,is a small enveloped virus whose positive-str...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-06, Vol.20 (23), p.7104-7122
Main Authors: Li, Hui-Chun, Ma, Hsin-Chieh, Yang, Chee-Hing, Lo, Shih-Yen
Format: Article
Language:English
Subjects:
Alternative
Animals
Antiviral Agents - therapeutic use
Core
Drug Design
Hepacivirus - drug effects
Hepacivirus - genetics
Hepacivirus - metabolism
Hepacivirus - pathogenicity
Hepatitis
Hepatitis C - drug therapy
Hepatitis C - virology
Host-Pathogen Interactions
Humans
Liver - drug effects
Liver - metabolism
Liver - virology
Molecular Targeted Therapy
protein
reading
Signal Transduction
Topic Highlight
Viral Core Proteins - genetics
Viral Core Proteins - metabolism
Virulence Factors - genetics
Virulence Factors - metabolism
virus
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Summary:Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes mellitus.HCV,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a polyprotein.The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various mechanisms.The peptide(a.a.178-191)may play a role in the immune response.The polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis development.In addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron metabolism.In this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i23.7104