VNP: Interactive Visual Network Pharmacology of Diseases, Targets, and Drugs

In drug discovery, promiscuous targets, multifactorial diseases, and “dirty” drugs construct complex network relationships. Network pharmacology description and analysis not only give a systems‐level understanding of drug action and disease complexity but can also help to improve the efficiency of t...

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Bibliographic Details
Published in:CPT: pharmacometrics and systems pharmacology 2014-03, Vol.3 (3), p.1-8
Main Authors: Hu, Q‐N, Deng, Z, Tu, W, Yang, X, Meng, Z‐B, Deng, Z‐X, Liu, J
Format: Article
Language:English
Subjects:
Acids
Alzheimer's disease
Bioinformatics
Clinical outcomes
Drugs
Hypertension
Original
Pharmacology
Proteins
R&D
Research & development
Software
Visualization
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Description
Summary:In drug discovery, promiscuous targets, multifactorial diseases, and “dirty” drugs construct complex network relationships. Network pharmacology description and analysis not only give a systems‐level understanding of drug action and disease complexity but can also help to improve the efficiency of target selection and drug design. Visual network pharmacology (VNP) is developed to visualize network pharmacology of targets, diseases, and drugs with a graph network by using disease, target or drug names, chemical structures, or protein sequence. To our knowledge, VNP is the first free interactive VNP server that should be very helpful for systems pharmacology research. VNP is freely available at http://cadd.whu.edu.cn/ditad/vnpsearch. CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e105; doi: 10.1038/psp.2014.1; published online 12 March 2014
ISSN:2163-8306
2163-8306
DOI:10.1038/psp.2014.1