Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis

Objective To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups. Methods ABILITY‐1 is...

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Bibliographic Details
Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-03, Vol.66 (3), p.667-673
Main Authors: Heijde, Désirée, Sieper, Joachim, Maksymowych, Walter P., Brown, Matthew A., Lambert, Robert G. W., Rathmann, Suchitrita S., Pangan, Aileen L.
Format: Article
Language:English
Subjects:
Adalimumab
Adult
Aged
Antibodies, Monoclonal, Humanized - therapeutic use
Antirheumatic Agents - therapeutic use
Female
Humans
Inflammation
Inflammation - complications
Inflammation - pathology
Male
Middle Aged
NMR
Nuclear magnetic resonance
Sacroiliitis - complications
Sacroiliitis - pathology
Severity of Illness Index
Spine - pathology
Spondylarthritis - complications
Spondylarthritis - drug therapy
Spondylarthritis - pathology
Spondyloarthritis
Treatment Outcome
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Summary:Objective To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups. Methods ABILITY‐1 is a multicenter, randomized, controlled trial of adalimumab versus placebo in patients with nonradiographic axial SpA classified using the Assessment of SpondyloArthritis international Society axial SpA criteria. Baseline MRIs were centrally scored independently by 2 readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) method for the SI joints and the SPARCC 6–discovertebral unit method for the spine. Positive evidence of inflammation on MRI was defined as a SPARCC score of ≥2 for either the SI joints or the spine. Results Among patients with baseline SPARCC scores, 40% had an SI joint score of ≥2 and 52% had a spine score of ≥2. Forty‐nine percent of patients with baseline SI joint scores of
ISSN:2326-5191
2326-5205
DOI:10.1002/art.38283