S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S...

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Bibliographic Details
Published in:Nature communications 2014-05, Vol.5 (1), p.3795-3795, Article 3795
Main Authors: Jaiswal, Jyoti K, Lauritzen, Stine P, Scheffer, Luana, Sakaguchi, Masakiyo, Bunkenborg, Jakob, Simon, Sanford M, Kallunki, Tuula, Jäättelä, Marja, Nylandsted, Jesper
Format: Article
Language:English
Subjects:
Actins - metabolism
Annexin A2 - metabolism
Calcium - metabolism
Cell Line, Tumor
Cell Membrane - pathology
Cell Movement
HeLa Cells
Humans
Ion Transport
MCF-7 Cells
Neoplasm Invasiveness - pathology
Neoplasm Metastasis - pathology
Neoplasms - pathology
Receptor, ErbB-2 - biosynthesis
Receptor, ErbB-2 - genetics
RNA Interference
RNA, Small Interfering
S100 Proteins - metabolism
Stress, Physiological
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Summary:Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein upregulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy of metastatic cancers.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms4795