Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens

RIG-I-like receptors (RLRs) play important roles in the host defense to numerous viral pathogens. Since they were discovered, much light has been shed on the molecular details of how these cytoplasmic viral RNA receptors sense viral infection and orchestrate antiviral innate immunity. Intriguingly,...

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Bibliographic Details
Published in:Journal of virology 2014-05, Vol.88 (10), p.5213-5216
Main Author: Gack, Michaela U
Format: Article
Language:English
Subjects:
Animals
DEAD-box RNA Helicases - metabolism
Gems
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Receptors, Immunologic - metabolism
RNA, Viral - immunology
Viruses - immunology
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Summary:RIG-I-like receptors (RLRs) play important roles in the host defense to numerous viral pathogens. Since they were discovered, much light has been shed on the molecular details of how these cytoplasmic viral RNA receptors sense viral infection and orchestrate antiviral innate immunity. Intriguingly, in addition to viral RNA binding, a series of posttranslational modifications (PTMs) is required for the rapid activation of RLRs and, inversely, for the prevention of aberrant innate immune signaling. Recent discoveries have shown that viruses manipulate the PTMs of RLRs to escape innate immune detection. This article highlights some of these recent findings in this fast-evolving field.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.03370-13