Non-platinum-based chemotherapy for treatment of advanced gastric cancer:5-fluorouracil,taxanes,and irinotecan

Despite numerous advances in treatment options,advanced gastric cancer(AGC)remains a major public health issue and the leading cause of cancer-related deaths.Cisplatin is one of the most effective broadspectrum anticancer drugs for AGC and a doublet combination regimen of either cisplatin-based or 5...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-05, Vol.20 (18), p.5396-5402
Main Authors: Kang, Byung Woog, Kim, Jong Gwang, Kwon, Oh-Kyoung, Chung, Ho Young, Yu, Wansik
Format: Article
Language:English
Subjects:
5-fluorouracil
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
cancer
Cisplatin
Fluorouracil - administration & dosage
Gastric
Humans
Iri
Patient Selection
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Taxane
Taxoids - administration & dosage
Topic Highlight
Treatment Outcome
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Description
Summary:Despite numerous advances in treatment options,advanced gastric cancer(AGC)remains a major public health issue and the leading cause of cancer-related deaths.Cisplatin is one of the most effective broadspectrum anticancer drugs for AGC and a doublet combination regimen of either cisplatin-based or 5-fluorouracil(5FU)-based chemotherapy is generally used for treatment of patients with AGC.However,there is still no consensus on the best regimen for treating AGC.Recently,various new chemotherapeutic agents,including oral 5FU,taxanes,and irinotecan,have been identified as improving the outcomes for AGC when used as a single agent or in combination with nonplatinum chemotherapy.Nonetheless,it is still unclear whether non-platinum-based chemotherapy is a viable treatment option for patients with AGC.Accordingly,this review focuses on the efficacy and tolerability of non-platinum-based chemotherapy for patients with AGC.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i18.5396