Genetic polymorphisms in Kawasaki disease

Kawasaki disease （KD） is an acute febrile systemic vasculitis, and the cause of KD is not well understood. It is likely due to multiple interactions between genes and environmental factors. The development of genetic association and genome-wide association studies （GWAS） has opened an avenue to bett...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2011-10, Vol.32 (10), p.1193-1198
Main Authors: Kuo, Ho-chang, Chang, Wei-chiao
Format: Article
Language:English
Subjects:
Animals
Genetic Predisposition to Disease
Humans
Mucocutaneous Lymph Node Syndrome - genetics
Mucocutaneous Lymph Node Syndrome - immunology
Phosphotransferases (Alcohol Group Acceptor) - genetics
Phosphotransferases (Alcohol Group Acceptor) - immunology
Polymorphism, Genetic
Review
信号通路
全基因组
分子机制
基因多态性
川崎
环境因素
相互作用
遗传多态性
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Summary:Kawasaki disease （KD） is an acute febrile systemic vasculitis, and the cause of KD is not well understood. It is likely due to multiple interactions between genes and environmental factors. The development of genetic association and genome-wide association studies （GWAS） has opened an avenue to better understanding the molecular mechanisms underlying KD. A novel ITPKC signaling pathway. was recently found to be responsible for the susceptibility to KD. Furthermore, the GWAS demonstrated the functionally related susceptibility loci for KD in the Caucasian population. In the last decade, the identification of several genomic regions linked to the pathogenesis of KD has made a major breakthrough in understanding the genetics of KD, This review will focus on genetic polymorphisms associated with KD and describe some of the possible clinical implications and molecular mechanisms that can be used to explain how genetic variants regulate the pathogenesis in KD.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2011.93