Histological grade concordance between diagnostic core biopsy and corresponding surgical specimen in HR-positive/ HER2-negative breast carcinoma

The identification and validation of suitable predictive and prognostic factors are a challenge to improve the treatment scheme selection. Discordances in histological grade can be established between core biopsy and surgical specimens. This is important in HR-positive/HER2-negative subgroup where h...

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Bibliographic Details
Published in:British journal of cancer 2014-04, Vol.110 (9), p.2195-2200
Main Authors: DAVEAU, C, BAULIES, S, COTTU, P, SABLIN, M. P, ROUZIER, R, MALHAIRE, C, MALLON, P, REYAL, F, LALLOUM, M, BOLLET, M, SIGAL-ZAFRANI, B, SASTRE, X, VINCENT-SALOMON, A, TARDIVON, A, THIBAULT, F, PIERGA, J. Y
Format: Article
Language:English
Subjects:
Automation
Biological and medical sciences
Biopsy
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer therapies
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - surgery
Chemotherapy
Clinical Study
Decision making
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical prognosis
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Grading
Neoplasm Invasiveness
Oncology
Patients
Receptor, ErbB-2 - genetics
Tumors
Ultrasonic imaging
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Summary:The identification and validation of suitable predictive and prognostic factors are a challenge to improve the treatment scheme selection. Discordances in histological grade can be established between core biopsy and surgical specimens. This is important in HR-positive/HER2-negative subgroup where histological grade identifies patients at high risk and is a strong determinant for treatment scheme. A total of 350 consecutive invasive breast carcinoma biopsies were assessed and compared with surgical specimens in Institut Curie, Paris, France. Clinical, radiological and pathological data were recorded. Histological grade concordance rate in the HR+/HER2- group was 75%. A grade underestimation was mainly due to mitotic index misgrading (23%). Large tumours (P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2014.143