The fate of regulatory T cells： survival or apoptosis

Foxp3＋ regulatory T cells （Tregs） are unique in their immunosuppressive abilities and contribution to immune regulation. However, the homeostatic processes and survival programs that maintain the Treg population remain unclear. Here, we highlight the recent study by Pierson et al.,1 which dissected...

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Bibliographic Details
Published in:Cellular & molecular immunology 2014-01, Vol.11 (1), p.11-13
Main Authors: Shen, Chia-Rui, Yang, Wei-Cheng, Chen, Hsin-Wei
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
eg细胞
Female
Forkhead Transcription Factors - metabolism
Immunoregulation
Lymphocytes T
Male
Proto-Oncogene Proteins c-bcl-2 - metabolism
Research Highlight
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
免疫能力
免疫调节作用
凋亡
稳态过程
解剖
调节性T细胞
调节机制
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Description
Summary:Foxp3＋ regulatory T cells （Tregs） are unique in their immunosuppressive abilities and contribution to immune regulation. However, the homeostatic processes and survival programs that maintain the Treg population remain unclear. Here, we highlight the recent study by Pierson et al.,1 which dissected the regulatory mechanisms of Treg home- ostasis and survival.
ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2013.49