Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

BACKGROUND: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet....

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Published in:Nutrition & metabolism 2014-03, Vol.11 (1), p.15-15
Main Authors: Moreno, Mayara Franzoi, de Souza, Gabriel Inácio de Morais Honorato, Hachul, Ana Claudia Losinskas, dos Santos, Bruno, Okuda, Marcos Hiromu, Neto, Nelson Inácio Pinto, Boldarine, Valter Tadeu, Esposito, Elisa, Ribeiro, Eliane Beraldi, do Nascimento, Claudia Maria da Penha Oller, Ganen, Aline de Piano, Oyama, Lila Missae
Format: Article
Language:English
Subjects:
adiponectin
adipose tissue
Analysis
Animals
bioactive properties
chitosan
Diet
Drinking water
Fatty acids
functional foods
Functional foods & nutraceuticals
Health aspects
high fat diet
Inflammation
Insulin
Insulin resistance
interleukin-10
liver
Medical research
Medicine, Experimental
Metabolic disorders
mice
Molecular weight
Nutrition research
Obesity
phosphorylation
Proteins
risk reduction
Rodents
tap water
tumor necrosis factor-alpha
whey protein
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Summary:BACKGROUND: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. METHODS: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. RESULTS: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. CONCLUSIONS: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.
ISSN:1743-7075
1743-7075
DOI:10.1186/1743-7075-11-15