From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma

Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of a ubiquitin ligase complex, altering the specificity of the complex to induce the ubiquitylation and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), transcription f...

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Bibliographic Details
Published in:Cancer cell 2014-01, Vol.25 (1), p.9-11
Main Authors: Licht, Jonathan D., Shortt, Jake, Johnstone, Ricky
Format: Article
Language:English
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Summary:Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of a ubiquitin ligase complex, altering the specificity of the complex to induce the ubiquitylation and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), transcription factors essential for MM growth.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2013.12.019