Obesity and Headache: Part II - Potential Mechanism and Treatment Considerations

Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we wi...

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Bibliographic Details
Published in:Headache 2014-03, Vol.54 (3), p.459-471
Main Authors: Chai, Nu Cindy, Bond, Dale S., Moghekar, Abhay, Scher, Ann I., Peterlin, B. Lee
Format: Article
Language:English
Subjects:
body mass index
headache
Headaches
Humans
Migraine
Migraine Disorders - etiology
Migraine Disorders - physiopathology
Obesity
Obesity - complications
Obesity - physiopathology
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Summary:Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine–obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.
ISSN:0017-8748
1526-4610
DOI:10.1111/head.12297