Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis

The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and st...

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Bibliographic Details
Published in:Current cardiology reviews 2014-02, Vol.10 (1), p.29-37
Main Authors: Hollander, Maurits R, Horrevoets, Anton J G, van Royen, Niels
Format: Article
Language:English
Subjects:
Angiogenesis Inducing Agents - therapeutic use
Angiogenesis Inhibitors - therapeutic use
Animals
Bradykinin - physiology
Collateral Circulation - physiology
Coronary Artery Disease - physiopathology
Coronary Circulation - physiology
Coronary Vessels - physiology
Disease Models, Animal
Granulocyte Colony-Stimulating Factor - physiology
Granulocyte-Macrophage Colony-Stimulating Factor - physiology
Humans
Intercellular Signaling Peptides and Proteins - physiology
Macrophages - physiology
Mice
Monocytes - physiology
Muscle, Smooth, Vascular - physiology
Neovascularization, Physiologic - physiology
Neuregulins - physiology
Platelet-Rich Plasma - physiology
Receptors, Bradykinin - physiology
Signal Transduction - physiology
Stem Cells - physiology
Vascular Endothelial Growth Factor A - physiology
Vasodilator Agents - therapeutic use
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Summary:The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.
ISSN:1573-403X
1875-6557
DOI:10.2174/1573403X113099990003