The carbohydrate-active enzymes database (CAZy) in 2013

The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Funct...

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Bibliographic Details
Published in:Nucleic acids research 2014-01, Vol.42 (Database issue), p.D490-D495
Main Authors: Lombard, Vincent, Golaconda Ramulu, Hemalatha, Drula, Elodie, Coutinho, Pedro M, Henrissat, Bernard
Format: Article
Language:English
Subjects:
Carbohydrate Metabolism
Carbohydrates - chemistry
Databases, Protein
Enzymes - chemistry
Enzymes - classification
Enzymes - genetics
Genome
III. Metabolic and signalling pathways, enzymes
Internet
Life Sciences
Ligands
Protein Conformation
Sequence Analysis, Protein
Substrate Specificity
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Summary:The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Functional and 3D structural information is added and curated on a regular basis based on the available literature. In addition to the use of the database by enzymologists seeking curated information on CAZymes, the dissemination of a stable nomenclature for these enzymes is probably a major contribution of CAZy. The past few years have seen the expansion of the CAZy classification scheme to new families, the development of subfamilies in several families and the power of CAZy for the analysis of genomes and metagenomes. This article outlines the changes that have occurred in CAZy during the past 5 years and presents our novel effort to display the resolution and the carbohydrate ligands in crystallographic complexes of CAZymes.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkt1178