Acute and delayed protective effects of pharmacologically induced hypothermia in an intracerebral hemorrhage stroke model of mice

Highlights • Pharmacologically induced hypothermia (PIH) was achieved in an intracerebral hemorrhage (ICH) stroke model of the mouse. • PIH initiated either 1 or 24 h after ICH reduced brain edema, BBB disruption, and cell death in the ICH brain. • PIH decreased the expression of MMP-9 and caspase-3...

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Bibliographic Details
Published in:Neuroscience 2013-11, Vol.252, p.489-500
Main Authors: Wei, S, Sun, J, Li, J, Wang, L, Hall, C.L, Dix, T.A, Mohamad, O, Wei, L, Yu, S.P
Format: Article
Language:English
Subjects:
ABS-201
Animals
Biological and medical sciences
Blotting, Western
Brain Edema - etiology
Cerebral Hemorrhage - metabolism
Cerebral Hemorrhage - pathology
Cerebral Hemorrhage - therapy
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
HPI-201
Hypothermia, Induced - methods
Immunohistochemistry
In Situ Nick-End Labeling
intracerebral hemorrhage
Male
Medical sciences
Mice
Mice, Inbred C57BL
Neurology
neurotensin receptor
pharmacological hypothermia
PIH
Recovery of Function
Stroke - metabolism
Stroke - pathology
Stroke - therapy
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Highlights • Pharmacologically induced hypothermia (PIH) was achieved in an intracerebral hemorrhage (ICH) stroke model of the mouse. • PIH initiated either 1 or 24 h after ICH reduced brain edema, BBB disruption, and cell death in the ICH brain. • PIH decreased the expression of MMP-9 and caspase-3 and increased the bcl-2 level in the ICH brain. • PIH treatment showed potential of improving functional recovery after hemorrhagic stroke.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.052