Assessment of avoidance behaviors in mouse models of muscle pain

Highlights • In an inflammatory muscle pain model we observe enhanced avoidance behaviors to noxious stimuli and physical activity. • In a non-inflammatory muscle pain model there are minimal changes in avoidance behaviors to noxious stimuli. • In a non-inflammatory muscle pain model there is increa...

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Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.54-60
Main Authors: Pratt, D, Fuchs, P.N, Sluka, K.A
Format: Article
Language:English
Subjects:
analgesia
Animals
Avoidance Learning
Biological and medical sciences
Carrageenan
Disease Models, Animal
Escape Reaction
escape-avoidance
Fundamental and applied biological sciences. Psychology
hyperalgesia
Hyperalgesia - psychology
inflammation
Inflammation - chemically induced
Male
Medical sciences
Mice
Mice, Inbred C57BL
Myalgia - psychology
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
pain
Physical Conditioning, Animal
Vertebrates: nervous system and sense organs
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Summary:Highlights • In an inflammatory muscle pain model we observe enhanced avoidance behaviors to noxious stimuli and physical activity. • In a non-inflammatory muscle pain model there are minimal changes in avoidance behaviors to noxious stimuli. • In a non-inflammatory muscle pain model there is increased avoidance of physical activity. • In exercise-enhanced muscle pain, there are no changes in avoidance behaviors to noxious stimuli or physical activity.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.05.058