Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure

The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known for its vasoconstrictive and proliferative effects. Angiotensin-converting enzyme 2 (ACE2), a newly discovered homolog of ACE...

Full description

Saved in:
Bibliographic Details
Published in:Current heart failure reports 2014-03, Vol.11 (1), p.58-63
Main Authors: Chamsi-Pasha, Mohammed A. R., Shao, Zhili, Tang, W. H. Wilson
Format: Article
Language:English
Subjects:
Angiotensin I - biosynthesis
Cardiac Surgery
Cardiology
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Heart Failure - drug therapy
Heart Failure - physiopathology
Humans
Hypertension - physiopathology
Imaging
Internal Medicine
Medicine
Medicine & Public Health
Molecular Targeted Therapy - methods
Peptide Fragments - biosynthesis
Peptidyl-Dipeptidase A - drug effects
Peptidyl-Dipeptidase A - physiology
Pharmacologic Therapy (WHW Tang
Pharmacologic Therapy (WHW Tang, Section Editor)
Radiology
Renin-Angiotensin System - physiology
Section Editor
Vascular Surgery
Ventricular Remodeling - physiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known for its vasoconstrictive and proliferative effects. Angiotensin-converting enzyme 2 (ACE2), a newly discovered homolog of ACE, plays a key role as the central negative regulator of the RAS. It diverts the generation of vasoactive Ang-II into the vasodilatory and growth inhibiting peptide angiotensin(1–7) [Ang(1–7)], thereby providing counter-regulatory responses to neurohormonal activation. There is substantial experimental evidence evaluating the role of ACE2/Ang(1–7) in hypertension, heart failure, and atherosclerosis. In this review, we aim to focus on the conceptual facts of the ACE2-Ang(1–7) axis with regards to clinical implications and therapeutic targets in cardiovascular disorders, with emphasis on the potential therapeutic role in cardiovascular diseases.
ISSN:1546-9530
1546-9549
DOI:10.1007/s11897-013-0178-0