Maternal Body-Mass Index and Cord Blood Circulating Endothelial Colony-Forming Cells

Objective Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord blood is associated with maternal body-mass index (BMI) in nonpathologic pregnanci...

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Bibliographic Details
Published in:The Journal of pediatrics 2014-03, Vol.164 (3), p.566-571
Main Authors: Moreno-Luna, Rafael, PhD, Muñoz-Hernandez, Rocio, BS, Lin, Ruei-Zeng, PhD, Miranda, Maria L., MD, PhD, Vallejo-Vaz, Antonio J., MD, Stiefel, Pablo, MD, PhD, Praena-Fernández, Juan M., BS, Bernal-Bermejo, José, BS, Jimenez-Jimenez, Luis M., MD, PhD, Villar, José, MD, PhD, Melero-Martin, Juan M., PhD
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Cells, Cultured
Endothelial Cells - cytology
Female
Fetal Blood - cytology
Humans
Infant, Newborn
Male
Pediatrics
Pregnancy
Premature Birth - blood
Stem Cells - cytology
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Summary:Objective Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord blood is associated with maternal body-mass index (BMI) in nonpathologic pregnancies. Study design We measured the level of ECFCs in the cord blood of neonates (n = 27) born from non-obese healthy mothers with nonpathologic pregnancies and examined whether ECFC abundance correlated with maternal BMI. We also examined the effect of maternal BMI on ECFC phenotype and function using angiogenic and vasculogenic assays. Results We observed variation in ECFC abundance among subjects and found a positive correlation between prepregnancy maternal BMI and ECFC content (r = 0.51, P  = .007), which was independent of other obstetric factors. Despite this variation, ECFC phenotype and functionality were deemed normal and highly similar between subjects with maternal BMI
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.10.063