Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study

It has been well documented that the maturing oocyte is very vulnerable to changes in its micro-environment, the follicular fluid (FF). Recent research has focused on different components within this FF, like hormones, growth factors and metabolites, and how their concentrations are altered by diet...

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Published in:Reproductive biology and endocrinology 2014-02, Vol.12 (1), p.13-13
Main Authors: Valckx, Sara D M, Arias-Alvarez, Maria, De Pauw, Ingrid, Fievez, Veerle, Vlaeminck, Bruno, Fransen, Erik, Bols, Peter E J, Leroy, Jo L M R
Format: Article
Language:English
Subjects:
Adult
Analysis
Body mass index
Body Weight - physiology
Cross-Sectional Studies
Embryonic development
Fatty acids
Fatty Acids - metabolism
Female
Follicular Fluid - metabolism
Health aspects
Humans
Obesity
Obesity - diagnosis
Obesity - metabolism
Overweight - diagnosis
Overweight - metabolism
Physiological aspects
Reproductive Techniques, Assisted - trends
Studies
Weight control
Women
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Summary:It has been well documented that the maturing oocyte is very vulnerable to changes in its micro-environment, the follicular fluid (FF). Recent research has focused on different components within this FF, like hormones, growth factors and metabolites, and how their concentrations are altered by diet and the metabolic health of the mother. It has been proposed that fatty acids (FAs) are potential factors that influence oocyte maturation and subsequent embryo development. However, a thorough study of the specific FF FA composition per lipid fraction and how this may be affected by BMI is currently lacking. Therefore, we investigated the BMI-related concentration of FAs in the phospholipid (PL), cholesteryl-ester (CHE), triglyceride (TG) and non-esterified (NE) lipid fraction in the FF of women undergoing assisted reproductive treatment (ART). In this descriptive cross-sectional study, the FF of normal weight (18.5 ≤ BMI 
ISSN:1477-7827
1477-7827
DOI:10.1186/1477-7827-12-13