A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition

Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging and Amyvid™ ([18 F] Amyvid, [18 F] florbetapir, 18 F-AV-45) was recently approved by the US Food and Drug Administration as a clinical tool to estimate brain amyloid burden in patients be...

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Bibliographic Details
Published in:Molecular neurodegeneration 2014-02, Vol.9 (1), p.10-10, Article 10
Main Authors: Mitsis, Effie M, Bender, Heidi A, Kostakoglu, Lale, Machac, Josef, Martin, Jane, Woehr, Jennifer L, Sewell, Margaret C, Aloysi, Amy, Goldstein, Martin A, Li, Clara, Sano, Mary, Gandy, Sam
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Agreements
Alzheimer Disease - diagnostic imaging
Alzheimer's disease
Aniline Compounds
Brain research
Clinical medicine
Decision Making
Dementia - diagnostic imaging
Diagnosis
Diagnosis, Differential
Ethylene Glycols
FDA approval
Feedback
Female
Humans
Male
Medical research
Medicine
Medicine, Experimental
Middle Aged
Neurodegeneration
Neuropathology
Nuclear medicine
Older people
Pathology
Patients
Pharmaceuticals
Positron-Emission Tomography
Quality of Life
Radiopharmaceuticals
Studies
Urban Population
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Summary:Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging and Amyvid™ ([18 F] Amyvid, [18 F] florbetapir, 18 F-AV-45) was recently approved by the US Food and Drug Administration as a clinical tool to estimate brain amyloid burden in patients being evaluated for cognitive impairment or dementia. Imaging with [18 F] florbetapir offers in vivo confirmation of the presence of cerebral amyloidosis and may increase the accuracy of the diagnosis and likely cause of cognitive impairment (CI) or dementia. Most importantly, amyloid imaging may improve certainty of etiology in situations where the differential diagnosis cannot be resolved on the basis of standard clinical and laboratory criteria. A consecutive case series of 30 patients (age 50-89; 16 M/14 F) were clinically evaluated at a cognitive evaluation center of urban dementia center and referred for [18 F] florbetapir PET imaging as part of a comprehensive dementia workup. Evaluation included neurological examination and neuropsychological assessment by dementia experts. [18 F] florbetapir PET scans were read by trained nuclear medicine physicians using the qualitative binary approach. Scans were rated as either positive or negative for the presence of cerebral amyloidosis. In addition to a comprehensive dementia evaluation, post [18 F] florbetapir PET imaging results caused diagnoses to be changed in 10 patients and clarified in 9 patients. Four patients presenting with SCI were negative for amyloidosis. These results show that [18 F] florbetapir PET imaging added diagnostic clarification and discrimination in over half of the patients evaluated. Amyloid imaging provided novel and essential data that: (1) caused diagnosis to be revised; and/or (2) prevented the initiation of incorrect or suboptimal treatment; and/or (3) avoided inappropriate referral to an anti-amyloid clinical trial.
ISSN:1750-1326
1750-1326
DOI:10.1186/1750-1326-9-10