Readout strategy of an electro-optical coupled PET detector for time-of-flight PET/MRI

Combining PET with MRI in a single system provides clinicians with complementary molecular and anatomical information. However, existing integrated PET/MRI systems do not have time-of-flight (ToF) PET capabilities. This work describes an MRI-compatible front-end electronic system with ToF capabiliti...

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Bibliographic Details
Published in:	Physics in medicine & biology 2013-10, Vol.58 (20), p.7227-7238
Main Authors:	Bieniosek, M F, Olcott, P D, Levin, C S
Format:	Article
Language:	eng
Subjects:	Electrical Equipment and Supplies Magnetic Resonance Imaging - instrumentation Multimodal Imaging - instrumentation Optical Fibers Optical Phenomena PET PET/MRI Positron-Emission Tomography - instrumentation SiPM Time Factors time-of-flight
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Summary:	Combining PET with MRI in a single system provides clinicians with complementary molecular and anatomical information. However, existing integrated PET/MRI systems do not have time-of-flight (ToF) PET capabilities. This work describes an MRI-compatible front-end electronic system with ToF capabilities. The approach employs a fast arrival-time pickoff comparator to digitize the timing information, and a laser diode to drive a 10 m fiber-optic cable to optically transmit asynchronous timing information to a photodiode receiver readout system. The FWHM jitter of the comparator and this electo-optical link is 11.5 ps in response to a fast digital pulse. When configured with LYSO scintillation crystals and Hamamatsu MPPC silicon photo-multipliers the comparator and electro-optical link achieved a 511 keV coincidence time resolution of 254.7 ps +/− 8.0 ps FWHM with 3 × 3 × 20 mm3 crystals and 166.5 +/− 2.5 ps FWHM with 3 × 3 × 5 mm3 crystals.
ISSN:	0031-9155 1361-6560