Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associa...

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Published in:Cardiovascular diabetology 2014-01, Vol.13 (1), p.22-22
Main Authors: Mueller, Noel T, Duncan, Bruce B, Barreto, Sandhi M, Chor, Dora, Bessel, Marina, Aquino, Estela M L, Pereira, Mark A, Schmidt, Maria Inês
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Behavior
Blood Glucose - metabolism
Body mass index
Brazil - epidemiology
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Children & youth
Chronic illnesses
Cohort Studies
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Disease
Disease prevention
Epidemiology
Female
Health Status
Humans
Insulin resistance
Longitudinal Studies
Low income groups
Menarche - blood
Middle Aged
Obesity
Original Investigation
Prospective Studies
Puberty
Public health
Retrospective Studies
Risk Factors
Studies
Womens health
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Summary:Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associated with higher diabetes risk in Brazilian adults. We used data from 8,075 women aged 35-74 years in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had complete information on age at menarche, diabetes status, and covariates. Diabetes was defined based on self-reported physician diagnosis, medication use, and laboratory variables (fasting glucose, 2-hour glucose, and glycated hemoglobin). Poisson regression was used to generate risk ratios (RR) and 95% confidence intervals (CI). Menarche onset < 11 years [vs. 13-14 years (referent)] was associated with higher risk of diabetes (RR = 1.34; 95% CI: 1.14-1.57) after adjusting for sociodemographic factors, maternal education, maternal and paternal diabetes, and birth weight. This persisted after further control for BMI at age 20 years and relative leg length. Additionally, among those not taking diabetes medications, earlier menarche [
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-13-22