Immune deficiency could be an early risk factor for altered insulin sensitivity in antiretroviral-naive HIV-1-infected patients: the ANRS COPANA cohort

The relationships between immunovirological status, inflammatory markers, insulin resistance and fat distribution have not been studied in recently diagnosed (500/mm(3) as the reference), in addition to older age (β: +0.26 for a 10-year increase; P=0.01) and higher BMI (β: +0.07 for a 1-kg/m(2) incr...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral therapy 2012, Vol.17 (1), p.91-100
Main Authors: BOUFASSA, Faroudy, GOUJARD, Cécile, VIARD, Jean-Paul, CARLIER, Robert, LEFEBVRE, Bénédicte, YENI, Patrick, BOUCHAUD, Olivier, CAPEAU, Jacqueline, MEYER, Laurence, VIGOUROUX, Corinne
Format: Article
Language:English
Subjects:
Adipokines
Adipokines - blood
Adult
Africa South of the Sahara
Africa South of the Sahara - ethnology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Blood Glucose
Blood Glucose - analysis
Body Fat Distribution
Body Mass Index
C-Reactive Protein
C-Reactive Protein - analysis
CD4 Lymphocyte Count
Cohort Studies
Cytokines
Cytokines - blood
Endocrinology and metabolism
European Continental Ancestry Group
Female
France
France - epidemiology
Glucose Tolerance Test
HIV Infections
HIV Infections - blood
HIV Infections - ethnology
HIV Infections - immunology
HIV Infections - virology
Human health and pathology
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Insulin
Insulin - blood
Insulin Resistance
Insulin Resistance - immunology
Life Sciences
Lipoproteins
Lipoproteins - blood
Male
Medical sciences
Pharmacology. Drug treatments
Risk Factors
RNA, Viral
RNA, Viral - analysis
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The relationships between immunovirological status, inflammatory markers, insulin resistance and fat distribution have not been studied in recently diagnosed (500/mm(3) as the reference), in addition to older age (β: +0.26 for a 10-year increase; P=0.01) and higher BMI (β: +0.07 for a 1-kg/m(2) increase; P=0.003). In ART-naive patients, severe immune deficiency but not inflammation could be an early risk factor for altered insulin sensitivity.
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP1916