Protein-energy malnutrition alters IgA responses to rotavirus vaccination and infection but does not impair vaccine efficacy in mice

Highlights • Weanling undernutrition alters serum and stool IgA responses to rhesus rotavirus vaccination and murine rotavirus infection. • Undernutrition does not impair vaccine-acquired protection against rotavirus. • Undernutrition accelerates murine rotavirus shedding but does not impair viral c...

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Bibliographic Details
Published in:Vaccine 2013-12, Vol.32 (1), p.48-53
Main Authors: Maier, Elizabeth A, Weage, Kristina J, Guedes, Marjorie M, Denson, Lee A, McNeal, Monica M, Bernstein, David I, Moore, Sean R
Format: Article
Language:English
Subjects:
Allergy and Immunology
animal models
Animals
Antibodies, Viral - blood
Antibodies, Viral - immunology
Applied microbiology
Biological and medical sciences
blood serum
body weight
children
Children & youth
developing countries
Diarrhea
Diet
Disease Models, Animal
Environmental enteropathy
enzyme-linked immunosorbent assay
Epizootic diarrhea of infant mice
failure to thrive
feces
Fundamental and applied biological sciences. Psychology
immune response
Immunization
immunoglobulin A
Immunoglobulin A - immunology
Immunoglobulin G - blood
Immunoglobulin G - immunology
Malnutrition
Mice
Microbiology
Miscellaneous
protein energy malnutrition
Protein-Energy Malnutrition - immunology
pups
Rhesus rotavirus
Rodents
Rotavirus
Rotavirus - immunology
Rotavirus Infections - immunology
Rotavirus Infections - prevention & control
Rotavirus Vaccines - immunology
Studies
Tropical barrier
vaccination
vaccine development
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
viral shedding
Virology
weanlings
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Description
Summary:Highlights • Weanling undernutrition alters serum and stool IgA responses to rhesus rotavirus vaccination and murine rotavirus infection. • Undernutrition does not impair vaccine-acquired protection against rotavirus. • Undernutrition accelerates murine rotavirus shedding but does not impair viral clearance.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.10.072