Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma

PRL-3 is a member of phosphatases of regenerating liver family, characterized by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 has been implicated in multiple cancers. Here we examined the clinical significance of PRL-3 in gastric cancer together with its metast...

Full description

Saved in:
Bibliographic Details
Published in:Journal of translational medicine 2013-12, Vol.11 (1), p.309-309, Article 309
Main Authors: Xing, Xiaofang, Lian, Shenyi, Hu, Ying, Li, Ziyu, Zhang, Lianhai, Wen, Xianzi, Du, Hong, Jia, Yongning, Zheng, Zhixue, Meng, Lin, Shou, Chengchao, Ji, Jiafu
Format: Article
Language:English
Subjects:
Base Sequence
Blotting, Western
Breast cancer
Cancer patients
Cancer therapies
Care and treatment
Cell Line, Tumor
Colorectal cancer
Complications and side effects
Development and progression
DNA Primers
Female
Fluorescent Antibody Technique
Health aspects
Humans
Male
Medical research
Middle Aged
Neoplasm Metastasis
Neoplasm Proteins - metabolism
Patient outcomes
Phosphatases
Polymerase Chain Reaction
Prognosis
Protein Tyrosine Phosphatases - metabolism
Stomach cancer
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Studies
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PRL-3 is a member of phosphatases of regenerating liver family, characterized by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 has been implicated in multiple cancers. Here we examined the clinical significance of PRL-3 in gastric cancer together with its metastatic biological functions utilizing different structural mutants. PRL-3 expression was analyzed immunohistochemically in 196 gastric cancer patients and 21 cases of liver metastasis. A series of wild type PRL-3 or its mutant plasmids were expressed in BGC823 cells to investigate the relationship between its catalytic activity, cellular localization and metastatic potential in vitro. Positive staining of PRL-3 was observed in 19.4% (38/196) gastric cancer tissues compared with 76.2% (16/21) in liver metastasis. Statistical analysis revealed that PRL-3 expression correlated with lymph node metastasis and vascular invasion (P
ISSN:1479-5876
1479-5876
DOI:10.1186/1479-5876-11-309