Molecular and cellular analysis of human histamine receptor subtypes

Highlights ► This review provides a comprehensive summary of our knowledge on human histamine receptors. ► We critically discuss the limitations of currently available ligands. ► We highlight pitfalls associated with the use of histamine receptor antibodies ► We provide constructive suggestions for...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2013-01, Vol.34 (1), p.33-58
Main Authors: Seifert, Roland, Strasser, Andrea, Schneider, Erich H, Neumann, Detlef, Dove, Stefan, Buschauer, Armin
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Histamine Agonists - chemistry
Histamine Agonists - pharmacology
Histamine Antagonists - chemistry
Histamine Antagonists - pharmacology
Humans
Molecular Targeted Therapy
Receptors, Histamine - chemistry
Receptors, Histamine - classification
Receptors, Histamine - genetics
Receptors, Histamine - metabolism
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Description
Summary:Highlights ► This review provides a comprehensive summary of our knowledge on human histamine receptors. ► We critically discuss the limitations of currently available ligands. ► We highlight pitfalls associated with the use of histamine receptor antibodies ► We provide constructive suggestions for future research in the field.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2012.11.001