Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes

Advances in nanotechnology have provided powerful and efficient tools in the development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles have attracted a considerable...

Full description

Saved in:
Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2014-01, Vol.6 (1), p.40-60
Main Authors: Devulapally, Rammohan, Paulmurugan, Ramasamy
Format: Article
Language:English
Subjects:
Animals
Biodegradability
Biodegradation
Biomolecules
Cancer
Cell Line, Tumor
Conflicts of interest
Drug Carriers
Drug delivery
Drug delivery systems
Drug discovery
Drugs
Humans
Mice
Nanomedicine
Nanoparticles
Nanostructure
Nanotechnology
Peptides
Polymers
Proteins
Ribonucleic acid
Ribonucleic acids
RNA
RNA, Small Interfering
RNA-mediated interference
Therapy
Toxicity
Vaccines
Wire
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Advances in nanotechnology have provided powerful and efficient tools in the development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles have attracted a considerable attention for their ability to function as a possible carrier for target‐specific delivery of various drugs, genes, proteins, peptides, vaccines, and other biomolecules in humans without much toxicity. This review will specifically focus on the recent advances in polymer‐based nanocarriers for various drugs and small silencing RNA's loading and delivery to treat different types of cancer. WIREs Nanomed Nanobiotechnol 2014, 6:40–60. doi: 10.1002/wnan.1242 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1242