A clinical study to evaluate the efficacy of intravitreal Anti-VEGF therapy in treating macular edema due to retinal venous occlusions

A non-randomized, interventional study was carried out various types of retinal venous occlusions with significant macular edema who required an Anti-VEGF injection. One hundred and one consecutive patients diagnosed as a case of CRVO/HCRVO/BRVO were enrolled in the study provided they had significa...

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Bibliographic Details
Published in:Medical journal. Armed Forces India 2013-07, Vol.69 (3), p.260-267
Main Authors: Kumar, Poninder, Banarji, Ajay, Patyal, Sagarika, Gurunadh, V.S., Ahluwalia, T.S., Oli, Avadesh, Moulick, P.S., Makker, Anuradha
Format: Article
Language:English
Subjects:
Anti-VEGFs
BCVA
CMT
Macular edema
Original
RVOs
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Summary:A non-randomized, interventional study was carried out various types of retinal venous occlusions with significant macular edema who required an Anti-VEGF injection. One hundred and one consecutive patients diagnosed as a case of CRVO/HCRVO/BRVO were enrolled in the study provided they had significant macular edema. Atleast three intra-vitreal injections of Anti-VEGFs were given and both the pre and post injections BCVA and CMT on OCT were observed and analyzed. 87 patients (86.14%) showed a significant improvement of vision of atleast two lines on the Snellen's and mean BCVA improved from log MAR +1.084 to log MAR +0.455. CMT on OCT showed reduction in thickness after Anti-VEGF therapy in 99 patients out of 101 and mean CMT decreased from 586.30 μ at baseline to 329.50 μ. Both of these findings were statistically very significant. Anti-VEGF therapy had a marked improvement in BCVA along with a dramatic reduction in CMT in the vast majority of RVOs patients with no serious ocular or systemic side effects.
ISSN:0377-1237
DOI:10.1016/j.mjafi.2013.02.001