Detection of entorhinal layer II using Tesla magnetic resonance imaging

The entorhinal cortex lies in the mediotemporal lobe and has major functional, structural, and clinical significance. The entorhinal cortex has a unique cytoarchitecture with large stellate neurons in layer II that form clusters. The entorhinal cortex receives vast sensory association input, and its...

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Bibliographic Details
Published in:Annals of neurology 2005-04, Vol.57 (4), p.489-494
Main Authors: Augustinack, Jean C., van der Kouwe, Andre J. W., Blackwell, Megan L., Salat, David H., Wiggins, Christopher J., Frosch, Matthew P., Wiggins, Graham C., Potthast, Andreas, Wald, Lawrence L., Fischl, Bruce R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Vascular diseases and vascular malformations of the nervous system
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Summary:The entorhinal cortex lies in the mediotemporal lobe and has major functional, structural, and clinical significance. The entorhinal cortex has a unique cytoarchitecture with large stellate neurons in layer II that form clusters. The entorhinal cortex receives vast sensory association input, and its major output arises from the layer II and III neurons that form the perforant pathway. Clinically, the neurons in layer II are affected with neurofibrillary tangles, one of the two pathological hallmarks of Alzheimer's disease. We describe detection of the entorhinal layer II islands using magnetic resonance imaging. We scanned human autopsied temporal lobe blocks in a 7T human scanner using a solenoid coil. In 70 and 100μm isotropic data, the entorhinal islands were clearly visible throughout the anterior–posterior extent of entorhinal cortex. Layer II islands were prominent in both the magnetic resonance imaging and corresponding histological sections, showing similar size and shape in two types of data. Area borders and island location based on cytoarchitectural features in the mediotemporal lobe were robustly detected using the magnetic resonance images. Our ex vivo results could break ground for high‐resolution in vivo scanning that could ultimately benefit early diagnosis and treatment of neurodegenerative disease. Ann Neurol 2005;57:489–494
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.20426