Antioxidant properties of xanthones from Calophyllum brasiliense: prevention of oxidative damage induced by FeSO4

Background Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases. Oxidative stress refers to the imbalance between the production of ROS and the ability to scavenge these species through endogenous antioxidant systems. Since antioxidants can inhibit oxidative pro...

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Published in:BMC complementary and alternative medicine 2013-10, Vol.13 (1), p.262-262, Article 262
Main Authors: Blanco-Ayala, Tonali, Lugo-Huitrón, Rafael, Serrano-López, Elizabeth M, Reyes-Chilpa, Ricardo, Rangel-López, Edgar, Pineda, Benjamín, Medina-Campos, Omar Noel, Sánchez-Chapul, Laura, Pinzón, Enrique, Cristina, Trejo-Solis, Silva-Adaya, Daniela, Pedraza-Chaverrí, Josñ, Ríos, Camilo, de la Cruz, Verónica Pñrez, Torres-Ramos, Mónica
Format: Article
Language:English
Subjects:
Acids
Albumin
Antioxidants
Chemical properties
Dicotyledons
Free radicals
Funding
Health aspects
Homeostasis
Hydrogen peroxide
Hydroxides
Laboratory animals
Liver
Medical research
Medicinal plants
Oxidative stress
Prevention
Rainforests
Rodents
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Summary:Background Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases. Oxidative stress refers to the imbalance between the production of ROS and the ability to scavenge these species through endogenous antioxidant systems. Since antioxidants can inhibit oxidative processes, it becomes relevant to describe natural compounds with antioxidant properties which may be designed as therapies to decrease oxidative damage and stimulate endogenous cytoprotective systems. The present study tested the protective effect of two xanthones isolated from the heartwood of Calophyllum brasilienses against FeSO.sub.4-induced toxicity. Methods Through combinatory chemistry assays, we evaluated the superoxide (O.sub.2.sup.â--), hydroxyl radical (OH.sup.â), hydrogen peroxide (H.sub.2O.sub.2) and peroxynitrite (ONOO.sup.--) scavenging capacity of jacareubin (xanthone III) and 2-(3,3-dimethylallyl)-1,3,5,6-tetrahydroxyxanthone (xanthone V). The effect of these xanthones on murine DNA and bovine serum albumin degradation induced by an OH* generator system was also evaluated. Additionally, we investigated the effect of these xanthones on ROS production, lipid peroxidation and glutathione reductase (GR) activity in FeSO.sub.4-exposed brain, liver and lung rat homogenates. Results Xanthone V exhibited a better scavenging capacity for O.sub.2.sup.â--, ONOO.sup.- and OH.sup.â than xanthone III, although both xanthones were unable to trap H.sub.2O.sub.2. Additionally, xanthones III and V prevented the albumin and DNA degradation induced by the OH.sup.â generator system. Lipid peroxidation and ROS production evoked by FeSO.sub.4 were decreased by both xanthones in all tissues tested. Xanthones III and V also prevented the GR activity depletion induced by pro-oxidant activity only in the brain. Conclusions Altogether, the collected evidence suggests that xanthones can play a role as potential agents to attenuate the oxidative damage produced by different pro-oxidants. Keywords: Xanthones, Antioxidant capacity, ROS production
ISSN:1472-6882
1472-6882
DOI:10.1186/1472-6882-13-262