Developmental disorders of the dentition: An update

Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insight...

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Published in:American journal of medical genetics. Part C, Seminars in medical genetics Seminars in medical genetics, 2013-11, Vol.163C (4), p.318-332
Main Authors: Klein, Ophir D., Oberoi, Snehlata, Huysseune, Ann, Hovorakova, Maria, Peterka, Miroslav, Peterkova, Renata
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - physiopathology
Animals
Anterior Eye Segment - abnormalities
Anterior Eye Segment - physiopathology
Cleft Lip - complications
Cleft Lip - physiopathology
Cleft lip/palate
Cleft Palate - complications
Cleft Palate - physiopathology
craniofacial
Cysts - complications
Cysts - physiopathology
Danio rerio
Dentition
Developmental Disabilities - complications
Developmental Disabilities - genetics
Developmental Disabilities - physiopathology
Ectodermal Dysplasia - complications
Ectodermal Dysplasia - physiopathology
Eye Abnormalities - complications
Eye Abnormalities - physiopathology
Genetics
Holoprosencephaly - complications
Holoprosencephaly - physiopathology
Humans
hypodontia
Lip - abnormalities
Lip - physiopathology
Mice
mouse
Orofaciodigital Syndromes - complications
Orofaciodigital Syndromes - physiopathology
supernumerary teeth
syndrome
teeth
Tooth - growth & development
Tooth - pathology
zebrafish
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Summary:Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insights into the genetics of tooth development obtained from mouse and zebrafish models. This is followed by a discussion of isolated as well as syndromic tooth agenesis, including Van der Woude syndrome (VWS), ectodermal dysplasias (EDs), oral‐facial‐digital (OFD) syndrome type I, Rieger syndrome, holoprosencephaly, and tooth anomalies associated with cleft lip and palate. Next, we review delayed formation and eruption of teeth, as well as abnormalities in tooth size, shape, and form. Finally, isolated and syndromic causes of supernumerary teeth are considered, including cleidocranial dysplasia and Gardner syndrome. © 2013 Wiley Periodicals, Inc.
ISSN:1552-4868
1552-4876
DOI:10.1002/ajmg.c.31382