Associations between COPD related manifestations: a cross-sectional study

Cardiovascular disease, osteoporosis and emphysema are associated with COPD. Associations between these factors and whether they predict all-cause mortality in COPD patients are not well understood. Therefore, we examined associations between markers of cardiovascular disease (coronary artery calcif...

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Bibliographic Details
Published in:	Respiratory research 2013-11, Vol.14 (1), p.129-129
Main Authors:	Romme, Elisabeth A P M, McAllister, David A, Murchison, John T, Van Beek, Edwin J R, Petrides, George S, Price, Cameron O S, Rutten, Erica P A, Smeenk, Frank W J M, Wouters, Emiel F M, MacNee, William
Format:	Article
Language:	eng
Subjects:	Aged Analysis Bone density Bone Density - physiology Bones Calcinosis - physiopathology Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Chronic obstructive pulmonary disease Comorbidity Complications and side effects Cross-Sectional Studies CT imaging Density Drug therapy Emphysema - epidemiology Emphysema - physiopathology Female Health aspects Heart diseases Humans Hypertension Kaplan-Meier Estimate Lung diseases, Obstructive Male Middle Aged Mortality Osteoporosis Osteoporosis - epidemiology Osteoporosis - physiopathology Patient outcomes Proportional Hazards Models Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - physiopathology Risk factors Survival Rate Vascular Stiffness - physiology Veins & arteries
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Summary:	Cardiovascular disease, osteoporosis and emphysema are associated with COPD. Associations between these factors and whether they predict all-cause mortality in COPD patients are not well understood. Therefore, we examined associations between markers of cardiovascular disease (coronary artery calcification [CAC], thoracic aortic calcification [TAC] and arterial stiffness), bone density (bone attenuation of the thoracic vertebrae), emphysema (PI-950 and 15th percentile) and all-cause mortality in a COPD cohort. We assessed CAC, TAC, bone attenuation of the thoracic vertebrae, PI-950 and 15th percentile on low-dose chest computed tomography in COPD subjects. We measured arterial stiffness as carotid-radial pulse wave velocity (PWV), and identified deaths from the national register. We studied 119 COPD subjects; aged 67.8 ±7.3, 66% were males and mean FEV1% predicted was 46.0 ±17.5. Subjects were classified into three pre-specificed groups: CAC = 0 (n = 14), 0 400 (n = 64). Subjects with higher CAC were more likely to be older (p
ISSN:	1465-9921 1465-993X 1465-993X