Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics

A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a ho...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2011-06, Vol.6 (2), p.247-259
Main Authors: Henderson, Lisa J., Al-Harthi, Lena
Format: Article
Language:English
Subjects:
Animals
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology
beta Catenin - physiology
Biomedical and Life Sciences
Biomedicine
Cell Biology
HIV Infections - drug therapy
HIV Infections - physiopathology
HIV-1 - drug effects
HIV-1 - physiology
Humans
Immunology
Invited Review
Neurosciences
Pharmacology/Toxicology
Signal Transduction - physiology
Transcription Factor 4
Transcription Factors - physiology
Virology
Virus Replication - drug effects
Virus Replication - physiology
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Summary:A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-011-9266-7