daily glass of red wine associated with lifestyle changes independently improves blood lipids in patients with carotid arteriosclerosis: results from a randomized controlled trial

BACKGROUND: Physical exercise and a Mediterranean diet improve serum lipid profile. The present work studied whether red wine has an effect on top of a lipid-lowering lifestyle in patients with carotid atherosclerosis. METHODS: A prospective randomised unblinded trial was performed from 2009 to 2011...

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Bibliographic Details
Published in:Nutrition journal 2013-11, Vol.12 (1), p.147-147
Main Authors: Droste, Dirk W, Iliescu, Catalina, Vaillant, Michel, Gantenbein, Manon, De Bremaeker, Nancy, Lieunard, Charlotte, Velez, Telma, Meyer, Michèle, Guth, Tessy, Kuemmerle, Andrea, Gilson, Georges, Chioti, Anna
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arteriosclerosis - blood
Arteriosclerosis - drug therapy
atherosclerosis
blood lipids
cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diet, Mediterranean
Endpoint Determination
exercise
Female
glass
high density lipoprotein
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Life Style
lifestyle
low density lipoprotein
Male
Mediterranean diet
men
Middle Aged
Motor Activity
patients
Prospective Studies
randomized clinical trials
red wines
therapeutics
triacylglycerols
Triglycerides - blood
Wine - classification
women
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Summary:BACKGROUND: Physical exercise and a Mediterranean diet improve serum lipid profile. The present work studied whether red wine has an effect on top of a lipid-lowering lifestyle in patients with carotid atherosclerosis. METHODS: A prospective randomised unblinded trial was performed from 2009 to 2011 in 108 patients with carotid atherosclerosis, 65% of whom were already on statin therapy with a low mean LDL of 104.9 mg/dl. Half of them were advised to follow a modified Mediterranean diet and to perform moderate physical exercise during 30 min/day (lifestyle changes) for 20 weeks. Within these two groups half of the patients were randomised either to avoid any alcohol or to drink 100 ml of red wine (women) or 200 ml of red wine (men) daily. RESULTS: LDL was significantly lowered by 7% in the lifestyle-changes group compared to the no-lifestyle-changes group (p = 0.0296) after 20 weeks. Lifestyle changes lowered the LDL/HDL ratio after 20 weeks by 8% (p = 0.0242) and red wine independently by 13% (p = 0.0049). The effect on LDL/HDL ratio after 20 weeks was, however, more pronounced in the non-LC group. Total cholesterol (−6%; p = 0.0238) and triglycerides (−13%; p = 0.0361) were lowered significantly by lifestyle changes after 20 weeks compared to the no-lifestyle-changes group. Lipoprotein (a) was not significantly affected by any intervention. The given results are per ITT analysis. CONCLUSIONS: Lifestyle changes including a modified Mediterranean diet and physical exercise as well as a glass of red wine daily improve independently the LDL/HDL ratio in patients with carotid arteriosclerosis even though the vast majority of them was already on statin therapy. TRIAL REGISTRATION: http://www.clinicaltrials.gov , NCT01146132
ISSN:1475-2891
1475-2891
DOI:10.1186/1475-2891-12-147