Reproductive Factors, Exogenous Hormones, and Pancreatic Cancer Risk in the CTS

Female steroid hormones are hypothesized to play a protective role in pancreatic cancer risk. However, results from epidemiologic studies that examined hormone-related exposures have been inconsistent. The California Teachers Study is a cohort study of female public school professionals that was est...

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Bibliographic Details
Published in:	American journal of epidemiology 2013-11, Vol.178 (9), p.1403-1413
Main Authors:	EUNJUNG LEE, HORN-ROSS, Pamela L, RULL, Rudolph P, NEUHAUSEN, Susan L, ANTON-CULVER, Hoda, URSIN, Giske, HENDERSON, Katherine D, BERNSTEIN, Leslie
Format:	Article
Language:	eng
Subjects:	Adult Age Age Factors Aged Biological and medical sciences Birth control Breast Feeding - statistics & numerical data California - epidemiology Contraceptives, Oral, Hormonal - administration & dosage Dose-Response Relationship, Drug Epidemiology Estrogen Replacement Therapy - statistics & numerical data Estrogens - administration & dosage Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Gynecology. Andrology. Obstetrics Hormones Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical research Medical sciences Menarche Menopause Middle Aged Miscellaneous Original Contributions Pancreatic cancer Pancreatic Neoplasms - epidemiology Parity Progestins - administration & dosage Proportional Hazards Models Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Smoking - epidemiology Tumors Womens health
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Summary:	Female steroid hormones are hypothesized to play a protective role in pancreatic cancer risk. However, results from epidemiologic studies that examined hormone-related exposures have been inconsistent. The California Teachers Study is a cohort study of female public school professionals that was established in 1995-1996. Of the 118,164 eligible study participants, 323 women were diagnosed with incident invasive pancreatic cancer through December 31, 2009. Multivariable Cox proportional hazards regression methods were used to estimate hazard ratios and 95% confidence intervals for the association of pancreatic cancer risk with reproductive factors and exogenous hormone use. Current users of estrogen-only therapy at baseline (1995-1996) had a lower risk of pancreatic cancer than did participants who had never used hormone therapy (hazard ratio = 0.59, 95% confidence interval: 0.42, 0.84). Use of estrogen-plus-progestin therapy was not associated with the risk of pancreatic cancer. A longer duration of oral contraceptive use (≥10 years of use compared with never use) was associated with an increased risk of cancer (hazard ratio = 1.72, 95% confidence interval: 1.19, 2.49). Reproductive factors, including age at menarche, parity, breastfeeding, and age at menopause, were not associated with pancreatic cancer risk. Our results suggest that increased estrogen exposure through estrogen-only therapy may reduce pancreatic cancer risk in women.
ISSN:	0002-9262 1476-6256