Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography

The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital‐mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-08, Vol.24 (31), p.4266-4270
Main Authors: Zhang, A. Ping, Qu, Xin, Soman, Pranav, Hribar, Kolin C., Lee, Jin W., Chen, Shaochen, He, Sailing
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
cell culture
extracelluar microenviroment
Extracellular Matrix - chemistry
Human Umbilical Vein Endothelial Cells
Humans
maskless lithography
Mice
Nanotechnology
NIH 3T3 Cells
optical projection stereolithography
soft material
Surface Properties
Tissue Engineering
Ultraviolet Rays
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Summary:The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital‐mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201202024