Arterial interventional chemotherapy and IMRT with concurrent chemotherapy for nasopharyngeal carcinoma with intracranial involvement

The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks af...

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Bibliographic Details
Published in:Oncology letters 2013-08, Vol.6 (2), p.427-431
Main Authors: FEN, XINGLAI, QIN, WEIFENG, BAO, WUAN, JIANG, FENG, LI, BIN, HU, FUJUN, CHEN, XIAOZHONG
Format: Article
Language:English
Subjects:
Brain cancer
Brain research
Chemotherapy
comprehensive treatment
Drug dosages
Hemorrhage
intensity modulated radiation therapy
interventional chemotherapy
Medical imaging
Metastasis
nasopharyngeal carcinoma
Oncology
Optic nerve
Radiation therapy
Throat cancer
Tumors
Veins & arteries
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Summary:The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. Primary tumor volume was reduced by 42.76% after 2 doses of interventional chemotherapy and intracranial tumor volume was reduced by 55.63%. All patients presented grade II and above nasopharyngeal mucositis. In the 2 years following radiotherapy, overall survival (OS) was 83.3% and progression-free survival (PFS) was 75%. In conclusion, T4 NPC patients with intracranial extension received induction chemotherapy followed by IMRT and concurrent chemotherapy, which proved to be efficacious and well tolerated.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1407