A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans

Abstract Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small ( N =12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operatio...

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Bibliographic Details
Published in:Psychiatry research 2013-04, Vol.206 (2), p.318-320
Main Authors: Naylor, Jennifer C, Dolber, Trygve R, Strauss, Jennifer L, Kilts, Jason D, Strauman, Timothy J, Bradford, Daniel W, Szabo, Steven T, Youssef, Nagy A, Connor, Kathryn M, Davidson, Jonathan R.T, Marx, Christine E
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Paroxetine
Paroxetine - therapeutic use
Pharmacology. Drug treatments
Pilot Projects
Post-traumatic stress disorder
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
PTSD
Serotonin Uptake Inhibitors - therapeutic use
Severity of Illness Index
Stress Disorders, Post-Traumatic - drug therapy
Subthreshold
Treatment Outcome
Veterans - psychology
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Summary:Abstract Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small ( N =12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2012.11.008