HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression

Highlights • We studied women with and without recurrent major depression, in remission. • rMDD women showed higher amygdala and hippocampus activity in response to stress. • In rMDD women, amygdala activity was negatively related to change in cortisol. • Amygdala activity was positively associated...

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Bibliographic Details
Published in:Neuroscience 2013-10, Vol.250, p.733-742
Main Authors: Holsen, L.M, Lancaster, K, Klibanski, A, Whitfield-Gabrieli, S, Cherkerzian, S, Buka, S, Goldstein, J.M
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - metabolism
Adult
Adult and adolescent clinical studies
Affect - physiology
Anxiety - psychology
Biological and medical sciences
Brain Mapping
Depression
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Female
fMRI
Fundamental and applied biological sciences. Psychology
HPA-axis
Humans
Hydrocortisone - blood
Hypothalamic Hormones - physiology
Hypothalamo-Hypophyseal System - physiology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Mood disorders
Nerve Net - physiopathology
Neurology
Pituitary Hormones - physiology
Prospective Studies
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
sex differences
Socioeconomic Factors
stress
Stress, Psychological - physiopathology
Stress, Psychological - psychology
Vertebrates: nervous system and sense organs
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Summary:Highlights • We studied women with and without recurrent major depression, in remission. • rMDD women showed higher amygdala and hippocampus activity in response to stress. • In rMDD women, amygdala activity was negatively related to change in cortisol. • Amygdala activity was positively associated with the duration of illness in rMDD women.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.042